Human-relevant Translational Drug Discovery with
Scalable, Reproducible Human Disease Models
We deliver advanced, human-relevant
3D spheroid and organoid models, enabling
By more accurately modeling chronic conditions
we help teams generate data that
better reflects human biology and treatment response
Our Services
Efficacy
We develop 3D spheroid and organoid assays that capture human tissue architecture, enabling robust measurement of compound efficacy in bone and other chronic disease indications
These high-throughput, plate-based models support hit-to-lead and lead optimisation campaigns, providing more predictive data than traditional 2D systems and helping prioritise candidates with the strongest translational potential
Mode of Action
Our spheroid and organoid platforms support early detection of off-target and organ-specific toxicity in human-like systems
By integrating viability, functional, and structural readouts, these assays highlight safety liabilities sooner, reduce reliance on animal studies, and enable smarter progression or termination decisions across discovery and pre-clinical development.
Toxicity
Our human-relevant models are designed to interrogate pathway-level responses, allowing teams to dissect cellular behaviours such as differentiation, matrix deposition, and remodeling under controlled conditions
By combining functional readouts with imaging and molecular endpoints, Navigate helps clarify mechanisms of action, validate targets, and generate mechanistic datasets that strengthen regulatory and partnering discussions
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